Association between ABO blood group and rheumatic diseases is not well characterized. This study assessed distribution of ABO blood group and Rh factor in patients with rheumatic diseases and healthy blood donors. We retrospectively evaluated data of patients with rheumatic diseases who attended the hospital from September 2015 to January 2020, and the documented evidence of blood group of healthy blood donors. Data from 5000 healthy donors and 3165 patients with rheumatic disease were assessed. Overall, blood type O was the most prevalent (42.94% and 43.14%) followed by B (33.21% and 30.08%), A (17.66% and 21.48%) and AB (6.19% and 5.30%) in patients with rheumatic disease and healthy donors, respectively. This distribution was statistically different between the groups, with blood group A being more common in healthy donors than in patients with rheumatic disease (P<0.0001). Distribution of ABO groups among rheumatic disease types was similar (P=0.2921). More individuals had Rhesus (Rh) (+) factor (93.97%) than Rh (-) (6.03%), however, its distribution was comparable across healthy donors and patients with rheumatic disease (P=0.1145). Patients with blood group A had significantly lower risk of developing rheumatic diseases compared to blood group O (OR [95% CI]: 0.94 [0.780, 1.134]; P<0.0318). Similarly, patients bearing blood type A+ (0.98 [0.62, 1.54]; P=0.0037) and O+ (1.08 [0.694, 1.68]; P=0.0215) were at a lower risk for developing rheumatic diseases compared to those with O- blood group. The most common blood type was O followed by B, A and AB in patients with rheumatic disease and healthy donors. Individuals with blood group A had lower risk of developing rheumatic diseases compared to other blood types.
| Published in | American Journal of Internal Medicine (Volume 9, Issue 3) |
| DOI | 10.11648/j.ajim.20210903.11 |
| Page(s) | 107-113 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
ABO Blood-group System, Blood Donors, Blood Groups, Rheumatic Diseases
| [1] | Chopra A. (2015). Disease burden of rheumatic diseases in India: COPCORD perspective. Indian Journal of Rheumatology, 10 (2), 70-77. |
| [2] | Kato M, Yasuda S, Atsumi T. (2018). The role of genetics and epigenetics in rheumatic diseases: are they really a target to be aimed at? Rheumatology International, 38 (8), 1333-1338. |
| [3] | Sparks JA, Costenbader KH. (2014). Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases. Rheumatic Diseases Clinics of North America, 40 (4), 637-657. |
| [4] | Van Steenbergen HW, Huizinga TW, van der Helm-van Mil AH. (2013). The preclinical phase of rheumatoid arthritis: what is acknowledged and what needs to be assessed? Arthritis and Rheumatism, 65 (9), 2219-2232. |
| [5] | Karadağ A. (2019). Comparison of distribution of blood groups in inflammatory rheumatic diseases and healthy subjects. Cumhuriyet Medical Journal, 41, 516-523. |
| [6] | Çildağ S, Kara Y, Şentürk T. (2017). ABO blood groups and rheumatic diseases. European Journal of Rheumatology, 4 (4), 250-253. |
| [7] | Franchini M, Liumbruno GM. (2013). ABO blood group: old dogma, new perspectives. Clinical Chemistry and Laboratory Medicine, 51 (8), 1545-1553. |
| [8] | Groot HE, Sierra LEV, Said MA, Lipsic E, Karper JC, van der Harst P. (2020). Genetically determined ABO blood group and its associations with health and disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 40 (3), 830-838. |
| [9] | Mouro I, Colin Y, Chérif-Zahar B, Cartron JP, Le Van Kim C. (1993). Molecular genetic basis of the human Rhesus blood group system. Nature Genetics, 5 (1), 62-65. |
| [10] | Liumbruno GM, Franchini M. (2013). Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood Transfusion=Trasfusione del sangue, 11 (4), 491-499. |
| [11] | Imberty A, Varrot A. (2008). Microbial recognition of human cell surface glycoconjugates. Current Opinion in Structural Biology, 18 (5), 567-576. |
| [12] | Zhang BL, He N, Huang YB, Song FJ, Chen KX. (2014). ABO blood groups and risk of cancer: a systematic review and meta-analysis. Asian Pacific Journal of Cancer Prevention: APJCP, 15 (11), 4643-4650. |
| [13] | Aird I, Bentall HH, Roberts JAF. (1953). A relationship between cancer of stomach and the ABO blood groups. British Medical Journal, 1 (4814), 799-801. |
| [14] | Franchini M, Favaloro EJ, Targher G, Lippi G. (2012). ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Critical Reviews in Clinical Laboratory Sciences, 49 (4), 137-149. |
| [15] | Kumar NC, Nadimpalli M, Vardhan VR, Gopal SD. (2010). Association of ABO blood groups with Chikungunya virus. Virology Journal, 7, 140. |
| [16] | Panda AK, Panda SK, Sahu AN, Tripathy R, Ravindran B, Das BK. (2011) Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis. Malaria Journal, 10, 309. |
| [17] | Meo SA, Rouq FA, Suraya F, Zaidi SZ. (2016) Association of ABO and Rh blood groups with type 2 diabetes mellitus. European Review for Medical and Pharmacological Sciences, 20 (2), 237-242. |
| [18] | Li C, Ouyang N, Wang X, Liang A, Mo Y, Li S, Qiu J, Fang G, Fu Y, Song B, Chen Z, Ding Y. (2019). Association between the ABO blood group and primary knee osteoarthritis: A case–control study. Journal of -Orthopaedic Translation, 21, 129-135. |
| [19] | Paré G, Chasman DI, Kellogg M, Zee RY, Rifai N, Badola S, Miletich JP, Ridker PM. (2008) Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS Genetics, 4 (7), e1000118. |
| [20] | Yi YS. (2018). Role of inflammasomes in inflammatory autoimmune rheumatic diseases. The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 22 (1), 1-15. |
| [21] | Hjeltnes G, Hollan I, Førre O, Wiik A, Lyberg T, Mikkelsen K, Agewall S. (2013). Serum levels of lipoprotein (a) and E-selectin are reduced in rheumatoid arthritis patients treated with methotrexate or methotrexate in combination with TNF-α-inhibitor. Clinical and Experimental Rheumatology, 31 (3), 415-421. |
| [22] | McMurray RW. (1996). Adhesion molecules in autoimmune disease. Seminars in Arthritis and Rheumatism, 25 (4), 215-233. |
| [23] | Stoia I, Ramneantu R, Poitas M. (1967). Blood groups ABO and Rh (D) factor in the rheumatic diseases. Annals of the Rheumatic Diseases, 26 (4), 332-333. |
| [24] | Farhud DD, Zarif Yeganeh M. (2013). A brief history of human blood groups. Iranian Journal of Public Health, 42 (1), 1-6. |
| [25] | Shekhar H, Kaur A, Jadeja P, Parihar PM, Mangukiya KK. (2014). Frequency and distribution of ABO blood group and Rh (D) factor in southern Rajasthan. International Journal of Science & Nature, 5 (3), 494-497. |
| [26] | Agrawal A, Tiwari AK, Mehta N, Bhattacharya P, Wankhede R, Tulsiani S, Kamath S. (2014). ABO and Rh (D) group distribution and gene frequency; the first multicentric study in India. Asian Journal of Transfusion Science, 8 (2), 121-125. |
| [27] | Shinebaum R, Blackwell CC, Forster PJ, Hurst NP, Weir DM, Nuki G. (1987), Non-secretion of ABO blood group antigens as a host susceptibility factor in the spondyloarthropathies. British Medical Journal (Clinical research ed.), 294 (6566), 208-210. |
| [28] | Tamega Ade A, Bezerra LV, Pereira Fde P, Miot HA. (2009) Blood groups and discoid lupus erythematosus. Anais Brasileiros de Dermatologia, 84 (5), 477-481. |
| [29] | Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; RACI consortium; GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM. (2014) Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506 (7488), 376-381. |
APA Style
Arindam Nandy Roy, Yarram Ashok Kumar, Regina Lata Thadigiri. (2021). A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India. American Journal of Internal Medicine, 9(3), 107-113. https://doi.org/10.11648/j.ajim.20210903.11
ACS Style
Arindam Nandy Roy; Yarram Ashok Kumar; Regina Lata Thadigiri. A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India. Am. J. Intern. Med. 2021, 9(3), 107-113. doi: 10.11648/j.ajim.20210903.11
AMA Style
Arindam Nandy Roy, Yarram Ashok Kumar, Regina Lata Thadigiri. A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India. Am J Intern Med. 2021;9(3):107-113. doi: 10.11648/j.ajim.20210903.11
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajim.20210903.11,
author = {Arindam Nandy Roy and Yarram Ashok Kumar and Regina Lata Thadigiri},
title = {A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India},
journal = {American Journal of Internal Medicine},
volume = {9},
number = {3},
pages = {107-113},
doi = {10.11648/j.ajim.20210903.11},
url = {https://doi.org/10.11648/j.ajim.20210903.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210903.11},
abstract = {Association between ABO blood group and rheumatic diseases is not well characterized. This study assessed distribution of ABO blood group and Rh factor in patients with rheumatic diseases and healthy blood donors. We retrospectively evaluated data of patients with rheumatic diseases who attended the hospital from September 2015 to January 2020, and the documented evidence of blood group of healthy blood donors. Data from 5000 healthy donors and 3165 patients with rheumatic disease were assessed. Overall, blood type O was the most prevalent (42.94% and 43.14%) followed by B (33.21% and 30.08%), A (17.66% and 21.48%) and AB (6.19% and 5.30%) in patients with rheumatic disease and healthy donors, respectively. This distribution was statistically different between the groups, with blood group A being more common in healthy donors than in patients with rheumatic disease (PP=0.2921). More individuals had Rhesus (Rh) (+) factor (93.97%) than Rh (-) (6.03%), however, its distribution was comparable across healthy donors and patients with rheumatic disease (P=0.1145). Patients with blood group A had significantly lower risk of developing rheumatic diseases compared to blood group O (OR [95% CI]: 0.94 [0.780, 1.134]; PP=0.0037) and O+ (1.08 [0.694, 1.68]; P=0.0215) were at a lower risk for developing rheumatic diseases compared to those with O- blood group. The most common blood type was O followed by B, A and AB in patients with rheumatic disease and healthy donors. Individuals with blood group A had lower risk of developing rheumatic diseases compared to other blood types.},
year = {2021}
}
TY - JOUR T1 - A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India AU - Arindam Nandy Roy AU - Yarram Ashok Kumar AU - Regina Lata Thadigiri Y1 - 2021/04/29 PY - 2021 N1 - https://doi.org/10.11648/j.ajim.20210903.11 DO - 10.11648/j.ajim.20210903.11 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 107 EP - 113 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20210903.11 AB - Association between ABO blood group and rheumatic diseases is not well characterized. This study assessed distribution of ABO blood group and Rh factor in patients with rheumatic diseases and healthy blood donors. We retrospectively evaluated data of patients with rheumatic diseases who attended the hospital from September 2015 to January 2020, and the documented evidence of blood group of healthy blood donors. Data from 5000 healthy donors and 3165 patients with rheumatic disease were assessed. Overall, blood type O was the most prevalent (42.94% and 43.14%) followed by B (33.21% and 30.08%), A (17.66% and 21.48%) and AB (6.19% and 5.30%) in patients with rheumatic disease and healthy donors, respectively. This distribution was statistically different between the groups, with blood group A being more common in healthy donors than in patients with rheumatic disease (PP=0.2921). More individuals had Rhesus (Rh) (+) factor (93.97%) than Rh (-) (6.03%), however, its distribution was comparable across healthy donors and patients with rheumatic disease (P=0.1145). Patients with blood group A had significantly lower risk of developing rheumatic diseases compared to blood group O (OR [95% CI]: 0.94 [0.780, 1.134]; PP=0.0037) and O+ (1.08 [0.694, 1.68]; P=0.0215) were at a lower risk for developing rheumatic diseases compared to those with O- blood group. The most common blood type was O followed by B, A and AB in patients with rheumatic disease and healthy donors. Individuals with blood group A had lower risk of developing rheumatic diseases compared to other blood types. VL - 9 IS - 3 ER -
Email: