Previous technologies may not be able provide radio-opaque biodegradable polymers that are degraded and completely eliminated by the body and also have good visibility when implanted in a human or an animal body. The study of radio opaque bioresorbable polymer such as poly lactide [poly-L-lactide (PLLA), poly-D-lactide (PDLA)], polyglycolide, polydioxanone, polycaprolactone, or related copolymers materials, each of which have a characteristic degradation rate in the body. Bioresorbable scaffold acts as radio opaque coating material to evaluate the flaking out/dissipation of coated material changes occur in morphological properties at specific temperatures with qualities in specific time period at specific intervals. This study covers radio opaque coating over bioresorbable polymeric implant intended for use in cardiovascular treatments. The coating was observed at interval of days at a specified temperature of 37°C. In X-ray film, the radio opaque coating of 50% TIBA on bioresorbable scaffold revealed excellent radiopacity and clear morphology. The development of new class of radio-opaque polymer i.e. biocompatible polymers with the capability of absorbing x-rays. In many clinical applications, it is highly desirable that an implant can be visualized via routine x-ray fluoroscopy. This allows the physician to monitor location and for implants in a non-invasive manner.
Published in | International Journal of Medical Imaging (Volume 10, Issue 3) |
DOI | 10.11648/j.ijmi.20221003.11 |
Page(s) | 29-32 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Radiopaque, Radiopacity, Bioresorbable/Biodegradable Scaffold, TIBA
[1] | Srivastava A., and Bhatnagar N. Production and characterisation of new bioresorbable radio opaque Mg-Zn-Y alloy to improve X-ray visibility of polymeric scaffold. Journal of Magnesium and Alloys. 2021: 1-25. |
[2] | Ang H. Y., Toong D., Chow W. S., and Seisilya W. et al. radio opaque fully degradable nanocomposites for coronary stents. Scientific reports. 2018. |
[3] | Chan W. A., Bini T. B., Venkatraman S. S., and Boey F. Y. C. Effect of radio opaque filler on biodegradable stent properties. Journal of Biomedical Materials Research Part A. 2006; 79 (1): 47 -52. |
[4] | Huang C. H., Lee S. Y., Horng S., Guy L. G., and Yu T. B. In vitro and in vivo degradation of microfiber bioresorbable coronary scaffold. Journal of Biomedical Materials Research B: Applied Biomaterials. 2018; 1068 (5): 1842 - 1850. |
[5] | Sigwart U., Urban P., Golf S., Kaufmann U., Imbert C., Fischer A., Kappenberger L. Emergency stenting for acute occlusion after coronary balloon angioplasty. Circulation. 1988; 78 (5): 1121 - 1127. |
[6] | Schmidt W., Behrens P., Wunderlich C. B., Siewert S., Grbow N., and Schmitz K. P. In vitro performance investigation of bioresorbable scaffolds - Standard tests for vascular stents and beyond. Cardiovascular Revasculation Medicine. 2016; 17 (6): 375 -383. |
[7] | Bian D., Qin Li., Lin W., Shen D., Qi H., Shi X., Zhang G., Liu H., Yang H., Wang J., Zhang j., Zhang D., and Zheng Y. Magnetic resonance (MR) safety and compatibility of a novel iron bioresorbable scaffold. 2020; 5 (2): 260 - 274. |
[8] | Roubin G. S., Douglas J. S., King S. B., Lin S. F., Hutchison N., and Gruentzing A. R. Influence of balloon size on initial success, acute complications, and restenosis after percutaneous transluminal coronary angioplasty. A prospective randomized study. Circulation. 1998; 78 (3): 557 - 565. |
[9] | Indolfi C., De Rosa S., and Colombo A. Bioresorbable vascular scaffolds [mdash] basic concepts and clinical outcome. Nat Rev Cardiol. 2016; 13: 719 -729. |
[10] | Venkatraman S. S., Tan L. P., Joso J. F., Boey Y. C. and Wang X. Biodegradable stents with elastic memory. Biomaterials. 2006; 27 (8): 1573 -1578. |
[11] | Chen Y., Xu Z., Smith C., and Sankar J. Recent advances on the development of magnesium alloys for biodegradable implants. Acta Biomater. 2014; 10 (11): 4561 -4573. |
[12] | Su S. H., Chao R. Y., Landau C. L., Nelson K. D., Timmons R. B., Meidell R. S., and Eberhart R. C. Expandable bioresorbable endovascular stent. I. Fabrication and properties. Ann Biomed Eng. 2003; 31 (6): 667 - 677. |
[13] | Alviar C. L., Tellez A., Wang M., Potts P. et al. Low dose sirolimus eluting hydroxyapatile coating on stents does not increase platelet activation and adhesion ex vivo. J Thromb Thrombolysis. 2012; 34: 91 - 98. |
[14] | Babapulle M. N., Eisenberg M. J. Coated stents for the prevention of restenosis: Part II. Circulation. 2002b; 106: 2859 - 2866. |
[15] | Basalus M., Ankone M., Van H. G., De M. F., Von B. C. Coating irregularities of durable polymer based drug eluting stents as assessed by scanning electron microscopy. EuroIntervention. 2009; 5: 157 - 165. |
[16] | Chen M. C., Tsai H. W., Chang Y., Lai W. Y., et al. Rapidly Self Expandable Polymeric Stents with a Shape Memory Property. Biomacromolecules. 2007; 8 (9): 2774 -2780. |
[17] | Garg S., Serruys P. W. Coronary stents: Looking forward. J Am Coll Cardiol. 2010; 56: S43 - S78. |
[18] | Hayman D., Bergerson C., Miller S., Moore J. E., and J. E. The effect of static and dynamic loading on degradation of PLLA stent fibers. J Biomech Eng. 2014; 136: 081006. |
[19] | Nuhn H., Blanco C. E., Desai T. A. Nano engineered stent surface to reduce in - stent restenosis in vivo. ACS Appl Mater Interfaces. 2017; 9: 19677 - 19686. |
[20] | Oberhauser J. P., Hossainy S., and Rapoza R. J. Design principles and performance of bioresorbable polymeric vascular scaffolds. Euro Intervention. 2009; 5: F15 - F22. |
[21] | Ormiston J. A., and Serruys P. W. Bioabsorbable coronary stents. Circ Cardiovasc Interv. 2009; 2: 255 - 260. |
[22] | Palmaz J. C. Intravascular stents: Tissue stent interaction and design consideration. AJR Am J Roentgenol. 1993; 160: 613 - 618. |
[23] | Peng T., Gibula P., and Goosen M. F. Role of polymers in improving the results of stenting in coronary arteries. Biomaterials. 1996; 17: 685 - 694. |
[24] | Puricel S et al. Comparasion of everolimus and biolimus eluting coronary stents with everolimus eluting bioresorbable vascular scaffold. J Am Coll Cardiol. 2015; 65: 791 - 801. |
[25] | Schmidt W., Lanzer P., Behrens P., Topoleski L., and Schmitz K. P. A comparison of the mechanical performance characteristics of seven drug eluting stent system. 2009; 73: 350 - 360. |
[26] | Sharkawi T., Cornchill F., Lafont A., Sabaria P., and Vert M. Intravascular bioresorbable polymeric stents: a potential alternative to current drug eluting metal stents. J Pharm Sci. 2007; 96: 2829 - 2837. |
[27] | Tan A., Alavijeh M. S., and Seifalian A. M. Next generation stent coatings: convergence of biotechnology and nanotachnology. Trends Biotechnol. 2012; 30: 406 - 409. |
[28] | Tanguay J. F., Zidar J., Phillips H., and Stack R. Current status of biodegradable stents. Cardiol Clin. 1994; 12: 699 - 713. |
APA Style
Dr. Pramod Kumar Minocha, Kothwala Deveshkumar Mahendralal, Dave Arpit Pradipkumar. (2022). Developing Radio Opaque Coating Study of Bioresorbable Scaffold. International Journal of Medical Imaging, 10(3), 29-32. https://doi.org/10.11648/j.ijmi.20221003.11
ACS Style
Dr. Pramod Kumar Minocha; Kothwala Deveshkumar Mahendralal; Dave Arpit Pradipkumar. Developing Radio Opaque Coating Study of Bioresorbable Scaffold. Int. J. Med. Imaging 2022, 10(3), 29-32. doi: 10.11648/j.ijmi.20221003.11
@article{10.11648/j.ijmi.20221003.11, author = {Dr. Pramod Kumar Minocha and Kothwala Deveshkumar Mahendralal and Dave Arpit Pradipkumar}, title = {Developing Radio Opaque Coating Study of Bioresorbable Scaffold}, journal = {International Journal of Medical Imaging}, volume = {10}, number = {3}, pages = {29-32}, doi = {10.11648/j.ijmi.20221003.11}, url = {https://doi.org/10.11648/j.ijmi.20221003.11}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20221003.11}, abstract = {Previous technologies may not be able provide radio-opaque biodegradable polymers that are degraded and completely eliminated by the body and also have good visibility when implanted in a human or an animal body. The study of radio opaque bioresorbable polymer such as poly lactide [poly-L-lactide (PLLA), poly-D-lactide (PDLA)], polyglycolide, polydioxanone, polycaprolactone, or related copolymers materials, each of which have a characteristic degradation rate in the body. Bioresorbable scaffold acts as radio opaque coating material to evaluate the flaking out/dissipation of coated material changes occur in morphological properties at specific temperatures with qualities in specific time period at specific intervals. This study covers radio opaque coating over bioresorbable polymeric implant intended for use in cardiovascular treatments. The coating was observed at interval of days at a specified temperature of 37°C. In X-ray film, the radio opaque coating of 50% TIBA on bioresorbable scaffold revealed excellent radiopacity and clear morphology. The development of new class of radio-opaque polymer i.e. biocompatible polymers with the capability of absorbing x-rays. In many clinical applications, it is highly desirable that an implant can be visualized via routine x-ray fluoroscopy. This allows the physician to monitor location and for implants in a non-invasive manner.}, year = {2022} }
TY - JOUR T1 - Developing Radio Opaque Coating Study of Bioresorbable Scaffold AU - Dr. Pramod Kumar Minocha AU - Kothwala Deveshkumar Mahendralal AU - Dave Arpit Pradipkumar Y1 - 2022/07/22 PY - 2022 N1 - https://doi.org/10.11648/j.ijmi.20221003.11 DO - 10.11648/j.ijmi.20221003.11 T2 - International Journal of Medical Imaging JF - International Journal of Medical Imaging JO - International Journal of Medical Imaging SP - 29 EP - 32 PB - Science Publishing Group SN - 2330-832X UR - https://doi.org/10.11648/j.ijmi.20221003.11 AB - Previous technologies may not be able provide radio-opaque biodegradable polymers that are degraded and completely eliminated by the body and also have good visibility when implanted in a human or an animal body. The study of radio opaque bioresorbable polymer such as poly lactide [poly-L-lactide (PLLA), poly-D-lactide (PDLA)], polyglycolide, polydioxanone, polycaprolactone, or related copolymers materials, each of which have a characteristic degradation rate in the body. Bioresorbable scaffold acts as radio opaque coating material to evaluate the flaking out/dissipation of coated material changes occur in morphological properties at specific temperatures with qualities in specific time period at specific intervals. This study covers radio opaque coating over bioresorbable polymeric implant intended for use in cardiovascular treatments. The coating was observed at interval of days at a specified temperature of 37°C. In X-ray film, the radio opaque coating of 50% TIBA on bioresorbable scaffold revealed excellent radiopacity and clear morphology. The development of new class of radio-opaque polymer i.e. biocompatible polymers with the capability of absorbing x-rays. In many clinical applications, it is highly desirable that an implant can be visualized via routine x-ray fluoroscopy. This allows the physician to monitor location and for implants in a non-invasive manner. VL - 10 IS - 3 ER -