Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure

Boyong Qiu; Wang Zheng; Suyun Yuan; Lin Shen; Duan Zhou; Shaofeng Wang; Yihong Wei

doi:doi:10.11648/j.sjph.20221002.13

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Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, Shaofeng Wang, Yihong Wei

Published in Science Journal of Public Health (Volume 10, Issue 2)

Received: 9 April 2022 Published: 14 April 2022

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Abstract

Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.

Published in	Science Journal of Public Health (Volume 10, Issue 2)
DOI	10.11648/j.sjph.20221002.13
Page(s)	87-91
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Heart Function, Heart Failure, Shen'ge Formula, Traditional Chinese Medicine

References

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APA Style

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, et al. (2022). Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Science Journal of Public Health, 10(2), 87-91. https://doi.org/10.11648/j.sjph.20221002.13

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ACS Style

Boyong Qiu; Wang Zheng; Suyun Yuan; Lin Shen; Duan Zhou, et al. Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Sci. J. Public Health 2022, 10(2), 87-91. doi: 10.11648/j.sjph.20221002.13

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AMA Style

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, et al. Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Sci J Public Health. 2022;10(2):87-91. doi: 10.11648/j.sjph.20221002.13

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@article{10.11648/j.sjph.20221002.13,
  author = {Boyong Qiu and Wang Zheng and Suyun Yuan and Lin Shen and Duan Zhou and Shaofeng Wang and Yihong Wei},
  title = {Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure},
  journal = {Science Journal of Public Health},
  volume = {10},
  number = {2},
  pages = {87-91},
  doi = {10.11648/j.sjph.20221002.13},
  url = {https://doi.org/10.11648/j.sjph.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20221002.13},
  abstract = {Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.},
 year = {2022}
}

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TY  - JOUR
T1  - Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure
AU  - Boyong Qiu
AU  - Wang Zheng
AU  - Suyun Yuan
AU  - Lin Shen
AU  - Duan Zhou
AU  - Shaofeng Wang
AU  - Yihong Wei
Y1  - 2022/04/14
PY  - 2022
N1  - https://doi.org/10.11648/j.sjph.20221002.13
DO  - 10.11648/j.sjph.20221002.13
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 87
EP  - 91
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20221002.13
AB  - Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.
VL  - 10
IS  - 2
ER  -

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Author Information

Boyong Qiu

The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
Wang Zheng

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Suyun Yuan

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Lin Shen

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Duan Zhou

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Shaofeng Wang

Chuansha Huaxia Community Health Service Center, Shanghai, China
Yihong Wei

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Plain Text BibTeX RIS

APA Style

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, et al. (2022). Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Science Journal of Public Health, 10(2), 87-91. https://doi.org/10.11648/j.sjph.20221002.13

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ACS Style

Boyong Qiu; Wang Zheng; Suyun Yuan; Lin Shen; Duan Zhou, et al. Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Sci. J. Public Health 2022, 10(2), 87-91. doi: 10.11648/j.sjph.20221002.13

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AMA Style

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, et al. Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Sci J Public Health. 2022;10(2):87-91. doi: 10.11648/j.sjph.20221002.13

Copy | Download

@article{10.11648/j.sjph.20221002.13,
  author = {Boyong Qiu and Wang Zheng and Suyun Yuan and Lin Shen and Duan Zhou and Shaofeng Wang and Yihong Wei},
  title = {Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure},
  journal = {Science Journal of Public Health},
  volume = {10},
  number = {2},
  pages = {87-91},
  doi = {10.11648/j.sjph.20221002.13},
  url = {https://doi.org/10.11648/j.sjph.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20221002.13},
  abstract = {Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure
AU  - Boyong Qiu
AU  - Wang Zheng
AU  - Suyun Yuan
AU  - Lin Shen
AU  - Duan Zhou
AU  - Shaofeng Wang
AU  - Yihong Wei
Y1  - 2022/04/14
PY  - 2022
N1  - https://doi.org/10.11648/j.sjph.20221002.13
DO  - 10.11648/j.sjph.20221002.13
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 87
EP  - 91
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20221002.13
AB  - Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.
VL  - 10
IS  - 2
ER  -

Copy | Download